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Beta 2 Microglubulin as a Marker for Vesicouretral Reflux in Children تاریخ ثبت : 1392/02/25
طبقه بندي :
Titel : Beta 2 Microglubulin as a Marker for Vesicouretral Reflux in Children
Author : M. Sharifian, A. Karimi and S. R. Tabatabaei
Journal : Emirates Medical Journal
Year : 2006
Volume : 24
Issue : 3
Pages : 215-218
Abstract :

Reflux nephropathy is one of the main causes of advanced renal failure in children the world over. Vesicoureteral reflux (VUR) is seen in 1.8% of the children; however, its prevalence is 34% in children suffering from urinary tract infections (UTI) and 40% in their siblings. The current study was carried out to evaluate the potential of replacing cystography (which requires exposure to radiation) by measuring urinary levels of β2-microglubolin in screening reflux. The urine samples of 83 children undergoing cystography were assessed for β2-microglubolin/creatinine (β2MG/Cr) ratio). There were 47 children suffering from VUR and 36 healthy children (55 girls and 28 boys). The urine samples were obtained during voiding cysto-urethrography (VCUG) and were evaluated for β2-microglubolin and creatinine. VUR was classified based on WHO classification and β2-microglubolin was reported in microgram to milligram of creatinine. Measurement of β2-microglubolin was performed using 96-test β2MG radioimmunoassay kit and creatinine by spectrophotometry using autoanalyzer. The mean β2MG/Cr ratio was significantly higher in children with VUR (7.97±3.45) than the children without VUR (0.24±0.23) (P= 0.01). The mean β2MG/Cr ratio in children with reflux grades 4 and 5 (12.01±8.93) was significantly higher than children with VUR of lower grades (3.04±0.81) (P = 0.02). The maximum β2MG/Cr ratio (23.3) was seen in a patient with VUR of grade 4 while the minimum of it (0) was observed in patients without reflux. The difference between β2MG/Cr ratio in the patients without reflux and the patients with lower grades of VUR (1-3) was not significant. The maximum β2MG/Cr ratio was 0.85 in patients without reflux. The maximum β2MG/Cr ratio was 0.85 in patients without reflux. This ratio can be assumed as the cutoff point for reflux screening. This study revealed that patients with grades 4 and 5 reflux have significantly higher β2MG/Cr ratios than patients without reflux or with lower degrees of reflux. Renal failure was very soon observed in 2 children with the highest amounts of β2MG/Cr suggesting that a simple urine test may demonstrate the prognosis. It is recommended to study the relationship between β2MG/Cr and renal scars.

 

Keywords : β2, Children, Microglubolin, Urinary tract infections, Vesicoureteral reflux
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